Background/goals: Colon most cancers stays a life-threating illness with rising morbidity and mortality worldwide regardless of the development in trendy medical remedy. Subsequently, novel and efficient anti-colon cancers medicine are urgently wanted. On this research, we investigated the anti-metastatic property EnDuo, a modified model of Endostar, and the underlying mechanisms.
Strategies: Colon most cancers cells had been handled with completely different concentrations of EnDuo (50 μg/mL, 100 μg/mL, 200 μg/mL), and Endostar (100 μg/mL) as optimistic management. Cell Counting Equipment-Eight assay was carried out to check the impact of EnDuo on cell viability. A scratch wound assay and transwell assay had been employed to judge the relocation and motility of malignant colon cells following remedy with EnDuo. Western blot evaluation was used to find out inhibitory results of EnDuo by detecting the phosphorylation degree of AKT and ERK proteins, and the expression of MMP-2 and MMP-9 proteins.
Outcomes: Our outcomes confirmed that EnDuo impedes the migration of colon most cancers cells in a dose-dependent method. On the molecular degree, EnDuo induced a major discount within the phosphorylation of AKT and ERK proteins, and inhibited the expression of MMP-2 and MMP-9 proteins.
Conclusions: Collectively, these outcomes display that EnDuo reveals a comparable anti-metastatic impact by suppressing the migration of colon most cancers cells. Presumably, EnDuo interrupts the PI3K/AKT/ERK signaling pathway to arrest cell migration. Our research supplies a novel perception to the potential medical functions of EnDuo towards colon cancers sooner or later.
Analysis of COVID-19 for controlling the pandemic: A overview of the state-of-the-art
Up to now, well being organizations and nations all over the world are struggling to fully management the unfold of the coronavirus illness 2019 (COVID-19). Scientists and researchers are growing assessments for the speedy detection of people who might carry the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2), whereas striving to discover a appropriate vaccine to immunize wholesome people. As there are clinically reported circumstances of asymptomatic carriers of SARS-CoV-2, quick and correct analysis performs an necessary position within the management and additional prevention of this illness. Herein, we current current applied sciences and strategies which have been carried out for the analysis of COVID-19.
We summarize the strategies created by completely different analysis institutes in addition to the business units and kits developed by corporations for the detection of SARS-CoV-2. The outline of the present strategies is adopted by highlighting their benefits and challenges. Lastly, we suggest some promising strategies that might probably be utilized to the detection of SARS-CoV-2, and tracing the asymptomatic carriers of COVID-19 quickly and precisely within the early levels of an infection, primarily based on reviewing the analysis research on the detection of comparable infectious viruses, particularly extreme acute respiratory syndrome (SARS) coronavirus, and Center East respiratory syndrome (MERS) coronavirus. Maglumi and iFlash had the very best analytical sensitivity for IgM and IgG, respectively. Axceed kits had a linearity response within the detected focus.
The medical sensitivity of Axceed, iFlash, and Maglumi was 68.0%, 64.9%, and 63.9% with a specificity of 99.0%, 96.0%, and 100% for IgM, 85.6%, 97.9%, and 94.8% with a specificity of 97.0% for IgG. ROC evaluation indicated all kits had a diagnostic energy larger than 0.9. Notably, both IgM or IgG kits obtained a poor settlement (Kappa worth from 0.397 to 0.713) with others. Amongst 38 recovered sufferers, 94.7% had an efficient immune response, and each seropositive IgM and IgG accounted for the most important proportion (medium, 42 days onset), then adopted by the only seropositive IgG (medium, 50 days onset) in Ab profile.

EnDuo, a novel derivative of Endostar, inhibits the migration of colon cancer cells, suppresses matrix metalloproteinase-2/9 expression and impedes AKT/ERK activation
MicroRNA-198 inhibits metastasis of thyroid most cancers by focusing on H3F3A
Goal: This research was designed to research the position of microRNA-198 in thyroid most cancers (TCa) development.
Sufferers and strategies: Quantitative real-time polymerase chain response (qRT-PCR) was carried out to look at microRNA-198 and H3F3A ranges in tumor tissue specimens and paracancerous ones collected from 50 sufferers with TCa, and the interaction between microRNA-198 or H3F3A and a few medical indicators or prognosis of TCa sufferers was analyzed as effectively. MicroRNA-198 and H3F3A overexpression fashions had been constructed utilizing lentivirus in TCa cell strains TPC-1 and BHP2-7, and the impacts of microRNA-198 on TCa cell features had been evaluated by utilizing cell counting equipment-8 (CCK-8), plate clone formation, and transwell assays. Lastly, restoration investigations had been carried out to discover the underlying mechanisms in addition to the interplay between microRNA-198 and H3F3A.
Outcomes: QRT-PCR indicated that in tumor tissues of TCa sufferers, microRNA-198 confirmed a remarkably decrease expression than in adjoining regular tissue samples. In contrast with sufferers with excessive expression of microRNA-198, these with microRNA-198 low expression had extra superior tumor stage, bigger tumor measurement, increased lymph node metastasis price, and decrease general survival price. In the meantime, the outcomes of analysis on H3F3A had been simply reverse to the above observations on microRNA-198. In in vitro cell experiments, overexpression of microRNA-198 considerably weakened the proliferation and migration means of thyroid tumor cells.
Annexin V Apoptosis Detection Kit (PE) |
abx290015-200test |
Abbexa |
200 test |
EUR 644.4 |
|
Annexin V-PE Apoptosis Detection Kit |
K128-100 |
Biovision |
each |
EUR 601.2 |
Annexin V-PE Apoptosis Detection Kit |
K128-25 |
Biovision |
each |
EUR 248.4 |
Annexin V-PE Apoptosis Detection Kit |
K128-400 |
Biovision |
each |
EUR 1149.6 |
Annexin V-PE Apoptosis Detection Kit |
K2200-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-PE Apoptosis Detection Kit |
K2200-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-PE Apoptosis Detection Kit |
K2200-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Annexin V Apoptosis Detection Kit (PE) (CY5) |
55R-1289 |
Fitzgerald |
25 assays |
EUR 416.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit Plus (PE) |
55R-1304 |
Fitzgerald |
25 assays |
EUR 363.6 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V / 7AAD Apoptosis Detection Kit (PE) |
abx290009-100test |
Abbexa |
100 test |
EUR 594 |
|
Annexin V Apoptosis Detection Kit : PE (OKTA00005) |
OKTA00005 |
Aviva Systems Biology |
KIT |
EUR 364.8 |
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: ;Sensitivity: |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K129-100 |
Biovision |
each |
EUR 588 |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K129-25 |
Biovision |
each |
EUR 301.2 |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K129-400 |
Biovision |
each |
EUR 1246.8 |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K2201-100 |
ApexBio |
100 assays |
EUR 668.4 |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K2201-25 |
ApexBio |
25 assays |
EUR 351.6 |
Annexin V-PE-Cy5 Apoptosis Detection Kit |
K2201-400 |
ApexBio |
400 assays |
EUR 1503.6 |
Annexin V Apoptosis Detection Kit (CY3) |
55R-1266 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit (CY5) |
55R-1267 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit (FITC) |
55R-1265 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit (FITC) |
abx290002-100test |
Abbexa |
100 test |
EUR 644.4 |
|
Annexin V Apoptosis Detection Kit (FITC) |
abx290014-200test |
Abbexa |
200 test |
EUR 577.2 |
|
Annexin V (PE) / 7-AAD Apoptosis Detection Kit (PE) |
abx090609-100tests |
Abbexa |
100 tests |
EUR 718.8 |
|
Annexin V Apoptosis Detection Kit (biotin) |
55R-1271 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit (Biotin) |
abx290017-200test |
Abbexa |
200 test |
EUR 744 |
|
Annexin V-PE/7-AAD Apoptosis Detection Kit |
A213-01 |
Vazyme |
50 rxn |
EUR 286.8 |
Annexin V-PE/7-AAD Apoptosis Detection Kit |
A213-02 |
Vazyme |
100 rxn |
EUR 369.6 |
Annexin V EGFP Apoptosis Detection Kit |
55R-1268 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V / PI Apoptosis Detection Kit (FITC) |
abx290007-100test |
Abbexa |
100 test |
EUR 543.6 |
|
Annexin V Apoptosis Detection Kit Plus (CY3) |
55R-1303 |
Fitzgerald |
25 assays |
EUR 355.2 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V Apoptosis Detection Kit Plus (FITC) |
55R-1302 |
Fitzgerald |
25 assays |
EUR 355.2 |
Description: Annexin V Apoptosis Kit for detection of apoptosis in the research laboratory |
Annexin V / PI Apoptosis Detection Kit (Biotin) |
abx290011-100test |
Abbexa |
100 test |
EUR 744 |
|
Annexin V Apoptosis Detection Kit (CF-Blue) |
abx290018-200test |
Abbexa |
200 test |
EUR 744 |
|
Annexin V Apoptosis Detection Kit (Dylight 634) |
abx290016-200test |
Abbexa |
200 test |
EUR 644.4 |
|
Annexin V (FITC) / PI Apoptosis Detection Kit |
abx090601-100tests |
Abbexa |
100 tests |
EUR 552 |
|
Annexin V-FITC/PI Apoptosis Detection Kit |
A211-01 |
Vazyme |
50 rxn |
EUR 259.2 |
Annexin V-FITC/PI Apoptosis Detection Kit |
A211-02 |
Vazyme |
100 rxn |
EUR 354 |
Annexin V Apoptosis Detection Kit : APC (OKTA00002) |
OKTA00002 |
Aviva Systems Biology |
KIT |
EUR 396 |
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity: |
Annexin V / 7ADD Apoptosis Detection Kit (FITC) |
abx290008-100test |
Abbexa |
100 test |
EUR 543.6 |
|
Annexin V Apoptosis Detection Kit : FITC (OKTA00003) |
OKTA00003 |
Aviva Systems Biology |
KIT |
EUR 380.4 |
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity: |
Annexin V / PI Apoptosis Detection Kit (CF-Blue) |
abx290012-100test |
Abbexa |
100 test |
EUR 678 |
|
Annexin V / PI Apoptosis Detection Kit (Dylight 634) |
abx290010-100test |
Abbexa |
100 test |
EUR 644.4 |
|
Annexin V (APC) / PI Apoptosis Detection Kit (APC) |
abx090605-100tests |
Abbexa |
100 tests |
EUR 777.6 |
|
Annexin V (FITC) / 7-AAD Apoptosis Detection Kit |
abx090603-100tests |
Abbexa |
100 tests |
EUR 594 |
|
Annexin V-FITC / PI Cell Apoptosis Detection Kit |
20-abx098246 |
Abbexa |
|
|
|
Annexin V-EGFP / PI Cell Apoptosis Detection Kit |
20-abx098247 |
Abbexa |
|
|
|
Annexin V / 7AAD Apoptosis Detection Kit (CF-Blue) |
abx290013-100test |
Abbexa |
100 test |
EUR 678 |
|
Annexin V (APC) / 7-AAD Apoptosis Detection Kit (APC) |
abx090607-100tests |
Abbexa |
100 tests |
EUR 811.2 |
|
CF594 TUNEL Assay Apoptosis Detection Kit |
30064 |
Biotium |
1KIT |
EUR 655.2 |
Description: Minimum order quantity: 1 unit of 1KIT |
CF640R TUNEL Assay Apoptosis Detection Kit |
30074 |
Biotium |
1KIT |
EUR 655.2 |
Description: Minimum order quantity: 1 unit of 1KIT |
CF488A TUNEL Assay Apoptosis Detection Kit |
30063 |
Biotium |
1KIT |
EUR 655.2 |
Description: Minimum order quantity: 1 unit of 1KIT |
Apoptosis Detection Kit |
ANXVKB-100T |
ImmunoStep |
100 test |
EUR 557.64 |
Apoptosis Detection Kit |
ANXVKCFB-100T |
ImmunoStep |
100 test |
EUR 495.24 |
Apoptosis Detection Kit |
ANXVKCFB7-100T |
ImmunoStep |
100 test |
EUR 495.24 |
Apoptosis Detection Kit |
ANXVKDY-100T |
ImmunoStep |
100 test |
EUR 467.16 |
Apoptosis Detection Kit |
ANXVKF-100T |
ImmunoStep |
100 test |
EUR 395.4 |
Apoptosis Detection Kit |
ANXVKF7-100T |
ImmunoStep |
100 test |
EUR 395.4 |
Apoptosis Detection Kit |
ANXVKPE-100T |
ImmunoStep |
100 test |
EUR 415.68 |
MitoStep + Apoptosis Detection PE |
KMAPE-100T |
ImmunoStep |
100 test |
EUR 551.4 |
MitoStep + Apoptosis Detection Kit |
KMAF-100T |
ImmunoStep |
100 test |
EUR 504.6 |
MitoCapture Apoptosis Detection Kit |
55R-1305 |
Fitzgerald |
25 assays |
EUR 332.4 |
Description: Apoptosis Kit for detection of apoptosis in the research laboratory |
TUNEL FITC Apoptosis Detection Kit |
A111-01 |
Vazyme |
20 rxn |
EUR 339.6 |
TUNEL FITC Apoptosis Detection Kit |
A111-02 |
Vazyme |
50 rxn |
EUR 490.8 |
TUNEL FITC Apoptosis Detection Kit |
A111-03 |
Vazyme |
100 rxn |
EUR 646.8 |
TUNEL BrightRed Apoptosis Detection Kit |
A113-01 |
Vazyme |
20 rxn |
EUR 367.2 |
TUNEL BrightRed Apoptosis Detection Kit |
A113-02 |
Vazyme |
50 rxn |
EUR 547.2 |
TUNEL BrightRed Apoptosis Detection Kit |
A113-03 |
Vazyme |
100 rxn |
EUR 786 |
TUNEL BrightGreen Apoptosis Detection Kit |
A112-01 |
Vazyme |
20 rxn |
EUR 367.2 |
TUNEL BrightGreen Apoptosis Detection Kit |
A112-02 |
Vazyme |
50 rxn |
EUR 547.2 |
TUNEL BrightGreen Apoptosis Detection Kit |
A112-03 |
Vazyme |
100 rxn |
EUR 786 |
Annexin V-PE Apoptosis Kit Plus |
K203-100 |
Biovision |
each |
EUR 582 |
Annexin V-PE Apoptosis Kit Plus |
K203-25 |
Biovision |
each |
EUR 280.8 |
Annexin V-PE Apoptosis Kit Plus |
K203-400 |
Biovision |
each |
EUR 1136.4 |
Annexin V-PE Apoptosis Kit Plus |
K2059-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-PE Apoptosis Kit Plus |
K2059-25 |
ApexBio |
25 assays |
EUR 301.2 |
Annexin V-PE Apoptosis Kit Plus |
K2059-400 |
ApexBio |
400 assays |
EUR 1270.8 |
Dual Apoptosis Assay with NucView 488 Caspase-3 Substrate and CF594 Annexin V (50 assays) |
30067 |
Biotium |
1KIT |
EUR 514.8 |
Description: Minimum order quantity: 1 unit of 1KIT |
CaspSCREEN Flow Cytometric Apoptosis Detection Kit |
55R-1301 |
Fitzgerald |
25 assays |
EUR 435.6 |
Description: Apoptosis Kit for use in the research laboratory |
CaspSCREEN? Flow Cytometric Apoptosis Detection Kit |
K200-100 |
Biovision |
each |
EUR 627.6 |
CaspSCREEN? Flow Cytometric Apoptosis Detection Kit |
K200-25 |
Biovision |
each |
EUR 333.6 |
Aposcreen Annexin V Apoptosis Kit : PE (OKSB00008) |
OKSB00008 |
Aviva Systems Biology |
100 Tests |
EUR 615.6 |
Description: Description of target: ;Species reactivity: ;Application: FC;Assay info: The ApoScreen Annexin V Apoptosis Kit employs a fluorescein- labeled annexin V (annexin V- FITC) in concert withpropidium iodide (PI) to evaluate subpopulations of cells undergoing apoptosis. During the early stages of apoptosis,cells begin to display PS on the outer cell membrane where it is readily detectable by staining the cells with annexin VFITC.As the plasma membrane becomes increasingly permeable during the later stages of apoptosis, PI can readilymove across the cell membrane and bind to cellular DNA, providing a means for identifying those cells that have lostmembrane integrity through mechanisms including necrosis. When cells are double stained with annexin V- FITC and PI,three different cell populations may be observed (Figure 2): (i) live cells that do not stain with either annexin V- FITC or PI;(ii) necrotic cells that stain with both reagents; and (iii) apoptotic cells that stain with annexin V- FITC only. Analysis canbe performed on any flow cytometer equipped with a single laser using excitation at 488 nm. Alternatively, the cells canbe examined with a fluorescence microscope equipped with filters for discrimination of FITC and rhodamine/PI.;Sensitivity: |
Mitochondrial Apoptosis Detection Fluorometric Kit |
K2097-100 |
ApexBio |
100 assays |
EUR 602.4 |
Mitochondrial Apoptosis Detection Fluorometric Kit |
K2097-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-Cy3 Apoptosis Kit |
K102-100 |
Biovision |
each |
EUR 601.2 |
Annexin V-Cy3 Apoptosis Kit |
K102-25 |
Biovision |
each |
EUR 248.4 |
Annexin V-Cy3 Apoptosis Kit |
K102-400 |
Biovision |
each |
EUR 1149.6 |
Annexin V-Cy5 Apoptosis Kit |
K103-100 |
Biovision |
each |
EUR 614.4 |
Annexin V-Cy5 Apoptosis Kit |
K103-25 |
Biovision |
each |
EUR 261.6 |
Annexin V-Cy5 Apoptosis Kit |
K103-400 |
Biovision |
each |
EUR 1227.6 |
Annexin V-Cy3 Apoptosis Kit |
K2004-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-Cy3 Apoptosis Kit |
K2004-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-Cy3 Apoptosis Kit |
K2004-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Annexin V-Cy5 Apoptosis Kit |
K2005-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-Cy5 Apoptosis Kit |
K2005-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-Cy5 Apoptosis Kit |
K2005-400 |
ApexBio |
400 assays |
EUR 1336.8 |
In Situ Fluorescein TUNEL Cell Apoptosis Detection Kit |
20-abx098881 |
Abbexa |
|
|
|
Annexin V-EGFP Apoptosis Kit |
K104-100 |
Biovision |
each |
EUR 601.2 |
Annexin V-EGFP Apoptosis Kit |
K104-25 |
Biovision |
each |
EUR 248.4 |
Annexin V-EGFP Apoptosis Kit |
K104-400 |
Biovision |
each |
EUR 1149.6 |
Annexin V-FITC Apoptosis Kit |
K101-100 |
Biovision |
each |
EUR 614.4 |
Annexin V-FITC Apoptosis Kit |
K101-25 |
Biovision |
each |
EUR 268.8 |
Annexin V-FITC Apoptosis Kit |
K101-400 |
Biovision |
each |
EUR 1227.6 |
Annexin V-FITC Apoptosis Kit |
K2003-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-FITC Apoptosis Kit |
K2003-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-FITC Apoptosis Kit |
K2003-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Annexin V-EGFP Apoptosis Kit |
K2006-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-EGFP Apoptosis Kit |
K2006-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-EGFP Apoptosis Kit |
K2006-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Annexin V-Biotin Apoptosis Kit |
K109-100 |
Biovision |
each |
EUR 561.6 |
Annexin V-Biotin Apoptosis Kit |
K109-25 |
Biovision |
each |
EUR 248.4 |
Annexin V-Biotin Apoptosis Kit |
K109-400 |
Biovision |
each |
EUR 1149.6 |
Annexin V-Biotin Apoptosis Kit |
K2009-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-Biotin Apoptosis Kit |
K2009-25 |
ApexBio |
25 assays |
EUR 285.6 |
Annexin V-Biotin Apoptosis Kit |
K2009-400 |
ApexBio |
400 assays |
EUR 1336.8 |
Annexin V-Cy3 Apoptosis Kit Plus |
K202-100 |
Biovision |
each |
EUR 588 |
Annexin V-Cy3 Apoptosis Kit Plus |
K202-25 |
Biovision |
each |
EUR 288 |
Annexin V-Cy3 Apoptosis Kit Plus |
K202-400 |
Biovision |
each |
EUR 1136.4 |
Annexin V-Cy3 Apoptosis Kit Plus |
K2058-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-Cy3 Apoptosis Kit Plus |
K2058-25 |
ApexBio |
25 assays |
EUR 301.2 |
Annexin V-Cy3 Apoptosis Kit Plus |
K2058-400 |
ApexBio |
400 assays |
EUR 1270.8 |
Annexin V-FITC Apoptosis Kit Plus |
K201-100 |
Biovision |
each |
EUR 601.2 |
Annexin V-FITC Apoptosis Kit Plus |
K201-25 |
Biovision |
each |
EUR 288 |
Annexin V-FITC Apoptosis Kit Plus |
K201-400 |
Biovision |
each |
EUR 1136.4 |
Annexin V-FITC Apoptosis Kit Plus |
K2057-100 |
ApexBio |
100 assays |
EUR 619.2 |
Annexin V-FITC Apoptosis Kit Plus |
K2057-25 |
ApexBio |
25 assays |
EUR 301.2 |
Annexin V-FITC Apoptosis Kit Plus |
K2057-400 |
ApexBio |
400 assays |
EUR 1270.8 |
Mitochondrial Apoptosis Detection Fluorometric Kit, MitoCapture |
K250-100 |
Biovision |
each |
EUR 588 |
Mitochondrial Apoptosis Detection Fluorometric Kit, MitoCapture |
K250-25 |
Biovision |
each |
EUR 274.8 |
Inhibitor of Apoptosis Protein Detection Set |
PSI-1815 |
ProSci |
1 Set |
EUR 1041.9 |
|
Description: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. This process can be interrupted by a family of proteins termed inhibitors of apoptosis (IAP). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR). These BIRs promote protein-protein interactions with members of the TRAF family of signaling molecules as well as caspases such as caspase-3, -7, and -9, and inhibiting the apoptotic activity of these proteins. Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Other IAPs include the X-linked protein XIAP/ILP-1, the related cIAP protein which exists in two distinct isoforms, Livin (also known as KIAP as it is highly expressed in kidney), Survivin/TIAP, ILP-2, and Bruce, an extremely large IAP with ubiquitin-conjugating enzyme activity. Upregulation of these proteins inhibit the normal apoptotic process and thus may be involved in human diseases such as cancer.;;For images please see PDF data sheet |
Aposcreen Annexin V Apoptosis Kit : FITC (OKSB00007) |
OKSB00007 |
Aviva Systems Biology |
100 Tests |
EUR 615.6 |
Description: Description of target: ;Species reactivity: ;Application: FC, ICC;Assay info: ;Sensitivity: |
Cell Meterâ„¢ Annexin V Binding Apoptosis Assay Kit *Blue Fluorescence Excited at 405 nm* |
22828-100Tests |
AAT Bioquest |
100 Tests |
EUR 222 |
|
Description: Our Cell Meterâ„¢ assay kits are a set of tools for monitoring cell viability. |
Cell Meterâ„¢ Annexin V Binding Apoptosis Assay Kit *Green Fluorescence Excited at 405 nm* |
22829-100Tests |
AAT Bioquest |
100 Tests |
EUR 222 |
|
Description: Our Cell Meterâ„¢ assay kits are a set of tools for monitoring cell viability. |
Cell Meter™ Annexin V Binding Apoptosis Assay Kit *Blue Fluorescence Excited at 405 nm* |
22828 |
AAT Bioquest |
100 Tests |
EUR 222 |
Apart from, Luciferase reporter gene experiment revealed that H3F3A was a selected goal gene for microRNA-198. Furthermore, qRT-PCR indicated that H3F3A and microRNA-198 had been negatively correlated in thyroid carcinoma tissues. As well as, in contrast with NC group, overexpression of H3F3A markedly enhanced the migration and proliferative capability of TCa cells. Lastly, restoration experiment revealed a mutual regulation between microRNA-198 and H3F3A, the 2 of which can collectively take part within the malignant development of TCa.