sebov-detection

Lethality and pathogenesis of airborne infection

 

Lethality and pathogenesis of airborne infection with filoviruses in A129 α/β -/- interferon receptor-deficient mice.

 

normal immunocompetent mice are not susceptible to the non-adjusted filoviruses. Therefore, there are two strategies available to build a model of murine infection Filovirus: adaptation of the virus to the host or the use of genetically modified mice that are susceptible to the virus. Some knockout (KO) strains of mice with defects either adaptive or innate immunity they are vulnerable to non-adjusted filoviruses.

 

 

In this study, A129 α / β – / – interferon receptor-deficient knockout mice, strain A129 IFN-α / β – / -, used to determine the lethal from various filoviruses, including Lake Victoria marburgvirus (Marv), Zaire ebolavirus (ZEBOV) , Sudan ebolavirus (SEBOV), Reston ebolavirus (REBOV) and Côte d’Ivoire ebolavirus (CIEBOV), administered using intraperitoneal (IP) or aerosol route of infection. One hundred percent mortality rate was observed in all groups given KO mice with different doses of Marv and ZEBOV challenge either by IP or aerosol route.

 

  • While it was dead because it depends on both the dose and ranged from 5.4 to 7.4 days in the challenges of IP injection, and 10.2 to 13 days in aerosol challenge. Lethal dose (50% tissue culture infective dose, TCID (50)) of ZEBOV to KO mice was <1 TCID (50) ml (-1) when administered either by IP or aerosol route of infection; for Marv lethal dose was <1 TCID (50) ml (-1) with the IP route of infection and <10 TCID (50) ml (-1) via the aerosol route.

  • In contrast, no mortality after infection with SEBOV or REBOV either by IP or aerosol route of infection; all rats lost weight (~ 15% loss of body weight means the group with SEBOV and ~ 7% with REBOV) but recovered to its original weight by day 14 post-challenge.

  • There were no deaths in the mice given the CIEBOV via the IP route of infection and no clinical signs of infection were observed.

  • More rapid disease progression after infection with ZEBOV than with Marv but eventually the two viruses cause widespread infection with high titer of infectious virus in some organs.

  • Histopathological observations are consistent with other animal models and showed extensive organ damage. This study shows that Marv and ZEBOV more sinister when administered via the IP route instead by aerosol infection, although both highly virulent by one of the routes.

  • KO mice could provide a useful model to test potential antiviral therapy against wild-type filoviruses.

 

sebov-detection

sebov-detection

 

 

PSMB8 Antibody
43134 100ul
EUR 319

PSMB8 Antibody
43134-100ul 100ul
EUR 302.4

PSMB8 Antibody
1-CSB-PA018886GA01HU
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  • 150ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

PSMB8 Antibody
1-CSB-PA018886LA01HU
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  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

PSMB8 Antibody
1-CSB-PA116429
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  • 50ul
  • 100ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 Antibody
1-CSB-PA775839
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  • 50ul
  • 100ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Antibody
E043134 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody
BF0434 200ul
EUR 540

PSMB8 Antibody
BF0434-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Antibody
BF0434-200ul 200ul Ask for price
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Antibody
BF0434-50ul 50ul
EUR 150
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Antibody
E94054 100μg
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody
E314816 100ug/200ul
EUR 295
Description: Available in various conjugation types.

PSMB8 Antibody
E97340 100ul
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody
MBS5312424-01mL 0.1mL
EUR 1070

PSMB8 Antibody
MBS5312424-5x01mL 5x0.1mL
EUR 4655

PSMB8 Antibody
MBS7113266-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7113266-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7113266-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody
MBS7129229-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7129229-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7129229-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody
MBS7129230-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7129230-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7129230-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody
MBS8500013-01mg 0.1mg
EUR 325

PSMB8 Antibody
MBS8500013-01mLAF405L 0.1mL(AF405L)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF405S 0.1mL(AF405S)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF610 0.1mL(AF610)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF635 0.1mL(AF635)
EUR 565

PSMB8 antibody
MBS9405580-01mL 0.1mL
EUR 420

PSMB8 antibody
MBS9405580-5x01mL 5x0.1mL
EUR 1740

PSMB8 Antibody
MBS9416351-01mL 0.1mL
EUR 305

PSMB8 Antibody
MBS9416351-5x01mL 5x0.1mL
EUR 1230

PSMB8 Polyclonal Antibody
A73468
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PSMB8 Conjugated Antibody
C43134 100ul
EUR 476.4

PSMB8 polyclonal antibody
BS91127 50ul
EUR 398
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

PSMB8 polyclonal antibody
BS78214 50ul
EUR 358
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

PSMB8 polyclonal antibody
BS8845 50 ul
EUR 358
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

PSMB8 Polyclonal Antibody
E-AB-92394-120uL 120uL
EUR 320
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-200uL 200uL
EUR 530
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-60uL 60uL
EUR 200
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-each each Ask for price
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-120uL 120uL
EUR 320
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-200uL 200uL
EUR 530
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-60uL 60uL
EUR 200
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-each each Ask for price
Description: Unconjugated

PSMB8 monoclonal antibody
MB66639 50ul
EUR 275
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

PSMB8 Polyclonal Antibody
MBS2538339-006mL 0.06mL
EUR 190

PSMB8 Polyclonal Antibody
MBS2538339-012mL 0.12mL
EUR 265

PSMB8 Polyclonal Antibody
MBS2538339-02mL 0.2mL
EUR 415

PSMB8 Polyclonal Antibody
MBS2538339-5x02mL 5x0.2mL
EUR 1835

PSMB8 Polyclonal Antibody
MBS2528965-002mL 0.02mL
EUR 140

PSMB8 Polyclonal Antibody
MBS2528965-006mL 0.06mL
EUR 180

PSMB8 Polyclonal Antibody
MBS2528965-012mL 0.12mL
EUR 260

PSMB8 Polyclonal Antibody
MBS2528965-02mL 0.2mL
EUR 405

PSMB8 Polyclonal Antibody
MBS2528965-5x02mL 5x0.2mL
EUR 1725

PSMB8 Polyclonal Antibody
MBS2527805-002mL 0.02mL
EUR 140

PSMB8 Polyclonal Antibody
MBS2527805-006mL 0.06mL
EUR 180

PSMB8 Polyclonal Antibody
MBS2527805-012mL 0.12mL
EUR 260

PSMB8 Polyclonal Antibody
MBS2527805-02mL 0.2mL
EUR 405

PSMB8 Polyclonal Antibody
MBS2527805-5x02mL 5x0.2mL
EUR 1725

PSMB8 Conjugated Antibody
MBS9451453-01mLAF350 0.1mL(AF350)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF405 0.1mL(AF405)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF488 0.1mL(AF488)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF555 0.1mL(AF555)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLBiotin 0.1mL(Biotin)
EUR 480

Vesicular stomatitis virus-based Ebola vaccine by increasing the cross-protective efficacy.

For Ebola virus (EBOV), 4 different species are known: Zaire, Sudan, Ivory Coast, and Reston ebolavirus. The newly discovered Bundibugyo ebolavirus has been proposed as a species-5. So far, there is no cross-neutralization between EBOV species have been described, the progress of cross-species exacerbate protective vaccine.

By using the vesicular stomatitis virus (rVSV) based recombinant vaccines, guinea pigs can be protected against Zaire ebolavirus (ZEBOV) infection only when immunized with vectors expressing homologous, but not heterologous, EBOV glycoprotein (GP).

However, infection of guinea pigs with the wild type strain nonadapted of different species resulted in the full protection of all animals against subsequent challenge with guinea pig-adapted ZEBOV, indicating that cross-species protection is possible.

The resulting new vector containing EBOV virus protein 40 (VP40) or EBOV nucleoprotein (NP) as second antigen expressed by the same rVSV vectors encoding the heterologous GP. After applying the 2 dose immunization approach, we observed increased levels of cross-protection, with 5 of 6 guinea pigs live ZEBOV lethal challenge when vaccinated with rVSV-GP-expressing SEBOV and -VP40.

Our data indicate that cross-protection between species EBOV can be achieved, although EBOV-GP alone can not induce an immune response that is required.

 

 

Mouse Fibroblast growth factor 5 ELISA Kit
MBS2880645-10x96StripWells 10x96-Strip-Wells
EUR 4080

Mouse Fibroblast growth factor 5 ELISA Kit
MBS2880645-48StripWells 48-Strip-Wells
EUR 390

Mouse Fibroblast growth factor 5 ELISA Kit
MBS2880645-5x96StripWells 5x96-Strip-Wells
EUR 2220

Mouse Fibroblast growth factor 5 ELISA Kit
MBS2880645-96StripWells 96-Strip-Wells
EUR 520

Mouse Fibroblast Growth Factor 5 ELISA Kit
MBS7256031-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Fibroblast Growth Factor 5 ELISA Kit
MBS7256031-48StripWells 48-Strip-Wells
EUR 485

Mouse Fibroblast Growth Factor 5 ELISA Kit
MBS7256031-5x96StripWells 5x96-Strip-Wells
EUR 3020

Mouse Fibroblast Growth Factor 5 ELISA Kit
MBS7256031-96StripWells 96-Strip-Wells
EUR 690

Mouse Growth/differentiation factor 5 (Gdf5)
1-CSB-EP009349MO
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  • 10ug
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  • 1MG
Description: Recombinant Mouse Growth/differentiation factor 5(Gdf5) expressed in E.coli

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MO 9462 mg Ask for price

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MO-100ug 100ug Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MO-1mg 1mg Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MO-20ug 20ug Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MOa0 10333 mg Ask for price

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MOa0-100ug 100ug Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MOa0-1mg 1mg Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
CSB-EP008632MOa0-20ug 20ug Ask for price
Description: 21-264aa

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
MBS959020-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1125

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
MBS959020-002mgEColi 0.02mg(E-Coli)
EUR 755

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
MBS959020-002mgYeast 0.02mg(Yeast)
EUR 915

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
MBS959020-01mgEColi 0.1mg(E-Coli)
EUR 905

Recombinant Mouse Fibroblast growth factor 5 (Fgf5)
MBS959020-01mgYeast 0.1mg(Yeast)
EUR 1070

ELISA Kit for Mouse Fibroblast growth factor 5
E0397m 96T
EUR 387.4

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
abx512829-96tests 96 tests
EUR 687.5

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
AE43665MO-48T 48T
EUR 325
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
AE43665MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
AE43665MO-96T 96T
EUR 610
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
AE43665MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
CSB-EL008632MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5 (FGF5) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
CSB-EL008632MO-48T 48T
EUR 338.81
Description: Mus musculus (Mouse)

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
1-CSB-EL008632MO
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  • 5 plates of 96 wells each
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Fibroblast growth factor 5(FGF5) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
CSB-EL008632MO-96T 96T
EUR 521.25
Description: Mus musculus (Mouse)

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKU11122-48T 48T
EUR 617.68

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKU11122-5x96T 5x96T
EUR 4191.4

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKU11122-96T 96T
EUR 882.4

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT
JOT-EK2072Mo 96 wells Ask for price
Description: Mouse

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT
E2072Mo-1096T 10*96T
EUR 4122

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT
E2072Mo-48wells 48 wells
EUR 300

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT
E2072Mo-596T 5*96T
EUR 2061

Mouse Fibroblast growth factor 5,FGF5 ELISA KIT
E2072Mo-96wells 96 wells
EUR 458

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
EKC36871-48T 48T
EUR 535.99

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
EKC36871-5x96T 5x96T
EUR 3637.08

Mouse Fibroblast growth factor 5(FGF5) ELISA kit
EKC36871-96T 96T
EUR 765.7

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKN52233-48T 48T
EUR 384.3

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKN52233-5x96T 5x96T
EUR 2607.75

Mouse Fibroblast Growth Factor 5 (FGF5) ELISA Kit
EKN52233-96T 96T
EUR 549

Mouse Fibroblast growth factor 5(FGF5) Elisa kit
EK730847 96 Wells
EUR 0.72

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS1604966-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS1604966-48StripWells 48-Strip-Wells
EUR 305

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS1604966-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS1604966-96StripWells 96-Strip-Wells
EUR 475

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
MBS2803671-10x96StripWells 10x96-Strip-Wells
EUR 6255

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
MBS2803671-48StripWells 48-Strip-Wells
EUR 445

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
MBS2803671-5x96StripWells 5x96-Strip-Wells
EUR 3290

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
MBS2803671-96StripWells 96-Strip-Wells
EUR 730

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS931255-10x96StripWells 10x96-Strip-Wells
EUR 5575

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS931255-24StripWellsLIMIT1 24-Strip-Wells(LIMIT1)
EUR 275

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS931255-48StripWells 48-Strip-Wells
EUR 545

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS931255-5x96StripWells 5x96-Strip-Wells
EUR 2920

Mouse Fibroblast growth factor 5, FGF5 ELISA Kit
MBS931255-96StripWells 96-Strip-Wells
EUR 765

Mouse Fibroblast growth factor 5 (FGF5) ELISA Kit
RK06732 96T
EUR 322.37

Fibroblast growth factor 5
AP89391 1mg
EUR 2640

Fibroblast growth factor 5
AP82670 1mg
EUR 2640

Fibroblast growth factor 5
AP82956 1mg
EUR 2640

Fibroblast growth factor 5
AP83077 1mg
EUR 2640

Fibroblast growth factor 5
AP83491 1mg
EUR 2640

Recombinant Mouse Growth/differentiation factor 5
MBS718033-002mgEColi 0.02mg(E-Coli)
EUR 320

Recombinant Mouse Growth/differentiation factor 5
MBS718033-01mgEColi 0.1mg(E-Coli)
EUR 520

Recombinant Mouse Growth/differentiation factor 5
MBS718033-1mgEColi 1mg(E-Coli)
EUR 1925

Recombinant Mouse Growth/differentiation factor 5
MBS718033-5x1mgEColi 5x1mg(E-Coli)
EUR 8405

Recombinant mouse Growth/differentiation factor 5
MBS9420263-002mg 0.02mg
EUR 380

Recombinant mouse Growth/differentiation factor 5
MBS9420263-01mg 0.1mg
EUR 650

Recombinant mouse Growth/differentiation factor 5
MBS9420263-1mg 1mg
EUR 2525

Recombinant mouse Growth/differentiation factor 5
MBS9420263-5x1mg 5x1mg
EUR 11205

Mouse Fibroblast Growth Factor 5, FGF5 GENLISA ELISA
KLM2072 1 x 96 wells
EUR 341

Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit
E01A21934 96T
EUR 700
Description: ELISA

Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit
E03F0069-48wellsplate 48 wells plate
EUR 280

Mouse Fibroblast growth factor 7/Keratin growth factor ELISA kit
E03F0069-96wellsplate 96 wells plate
EUR 405

Mouse Growth Differentiation Factor 5 CLIA Kit
MBS8426250-INQUIRE INQUIRE Ask for price

Mouse Growth Differentiation Factor 5 ELISA kit
E01A22208 96T
EUR 700
Description: ELISA

Mouse Growth Differentiation Factor 5 ELISA Kit
MBS020589-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Growth Differentiation Factor 5 ELISA Kit
MBS020589-48StripWells 48-Strip-Wells
EUR 550

Mouse Growth Differentiation Factor 5 ELISA Kit
MBS020589-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Growth Differentiation Factor 5 ELISA Kit
MBS020589-96StripWells 96-Strip-Wells
EUR 765